Dra. Rosa Ma. del Angel

Dra. Rosa Ma. del Angel

Dra. Rosa Ma. del Angel

Grado:Doctorado en Ciencias 1990
Departamento de Genética y Biología Molecular,
Centro de Investigación y de Estudios Avanzados del IPN.
México, D.F., México.

SNI: Nivel III

Teléfono: (525) 5747-7000 ext 5647 y 5648
Fax: (525) 747-71-07
E-mail: rmangel@cinvestav.mx

 

TEMAS DE INVESTIGACIÓN

Nuestro grupo esta dedicado al análisis de los mecanismos y componentes celulares que usan los virus de la familia Flaviviridae como Dengue, Zika y el virus del Fiebre amarilla para entrar, replicarse, inhibir la respuesta inmune celular y salir de la célula. Este estudio nos ha permitido encontrar factores que favorecen y otros que evitar la multiplicación viral en las células infectadas. Con esta información hemos identificado moléculas y componentes que son capaces de bloquear la infección por estos virus y estamos probando su utilidad como antivirales en sistemas de cultivos de células y en modelos animales.

Por otro lado, trabajamos en la identificación de mecanismos de comunicación celular como son los exosomas en las células de mosquito y su participación en la patogenia de la infección por Dengue.

 

RESEARCH INTEREST:

Our group is actually involved in the analysis of cellular mechanisms and components used by Flaviviridae family members such as Dengue, Zika and Yellow Fever virus to enter, replicate, inhibit the cellular immune response and exit the host cell. This study has allowed us to find cellular factors that favor and others that avoid viral multiplication in infected cells. With this information we have identified molecules and components that are capable to block viral infection and we are testing their usefulness as antivirals in cell culture systems and in animal models. On the other hand, we work on the identification of cellular communication mechanisms such as exosomes in mosquito cells and their participation in Dengue virus pathogenesis.

PUBLICACIONES

1.- Gariglio, P., del Angel, R.M., Herrera, A. and Bonilla, M. 1987. Theoretical model for the posttranscriptional regulation of the human c-myc gene expression, involving double-stranded RNA processing. J. Theor. Biol. 125: 83-92.

2.- Del Angel, R.M., Papavassiliou, A.G., Fernández-Tomás, C., Silverstein, S.J. and Racaniello, V.R. 1989. Cell proteins bind to multiple sites within the 5' untranslated region of poliovirus RNA. Proc. Natl. Acad. Sci. 86: 8299-8303.

3.- Gutierrez, L., Castro, E., del Angel, R.M., Soler, C. y Fernández-Tomás, C. 1994. Las Ribosondas: una alternativa en el diagnóstico de secuencias virales. Salud Pública Mex. 36:140-147.

4.- Rojas-Eisenring, I, Cajero-Juarez, M. and del Angel, R.M. 1995. Cell proteins bind to a linear polypyrimidine-rich sequence within the 5'-untranslated region of rhinovirus 14 RNA. J. Virol. 69:6819-6824.

5.- Villareal, M.T., Chavez, M., Lezana J.L., Cuevas, F., Carnevale, A., Córdova, E., del Angel, R.M. and Orozco, L. 1996. G542X mutation in mexican cystic fibrosis patients. Clin. Genet. 49:54-56.

6.- Gutiérrez-Escolano, L., del Angel R.M. 1996. Nuclear proteins bind to poliovirus 5' untranslated region. Arch. Med. Res. 27:413-419.

7.- Gutiérrez-Escolano, A.L., Medina, F., Racaniello, V.R. and del Angel, R.M. 1997. Differences in the UV-crosslinking patterns of the poliovirus 5'-untranslated region with cell proteins from poliovirussusceptible and resistant tissues. Virology 227:505-508.

8.- Gutiérrez-Escolano, A.L., Denova-Ocampo, M., Racaniello, V.R. and del Angel, R.M. 1997. Attenuating mutations in the poliovirus 5’-untranslated region alter its interaction with polypyrimidine tract-binding protein. J. Virol. 71:3826-3833.

9.-Orozco, L, Zielenski, J., Markiewics, D., Villarreal, T., Lamp-Arce T., Lezana, J.L. and del Angel, R.M. 1997. Two novel frame shift deletions (192del7,2055del9->A) in the CFTR gene in mexican cystic fibrosis patients. Hum. Mutat. 10:239-240.

10.- García, G., Vaughn, D. and del Angel R.M. 1997. Sera from dengue virus infected children recognize synthetic oligopeptides from NS1 and NS3 proteins from dengue 4 virus. Am. J. Trop. Med. Hyg. 56:466-470.

11.- Salas-Benito, J.S. and del Angel R.M. 1997. Identification of two surface proteins from C6/36 cells that bind dengue type 4 virus. J. Virol. 71:7246-7252.

12.- Gutiérrez-Escolano, A.L, Uribe-Brito, Z., del Angel, R.M. and Jiang, X. 2000. Interaction of cell proteins with the 5’ end of Norwalk virus genomic RNA. J. Virol 74:8558-8562.

13.- Martínez-Barragán, J.J. and del Angel, R.M. 2001. Identification of a putative coreceptor on Vero cells that participates in dengue 4 virus infection. J. Virol. 75:7818-7827.

14.- Mendoza, M.Y., Salas-Benito, J.S., Lanz-Mendoza, H., Hernández-Martínez, S. and del Angel, R.M. 2002. A putative receptor for dengue virus in mosquito tissues: Localization of a 45-kDa glycoprotein. Am. J. Trop. Med. Hyg. 67:76-84.

15.- De Nova-Ocampo, M., Villegas-Sepúlveda N., and del Angel R.M. 2002. Translation elongation factor-1a, La and PTB interact with the 3’ Untranslated Region of Dengue 4 Virus RNA. Virology. 295: 337-347.

16.- González-Herrera, L. , García- Escalante G., Castillo-Zapata I., Canto-Herrera J., Cevallos-Quintal J., Pinto-Escalante D, Díaz-Rubio F , Del Angel RM, Orozco-Orozco L. 2002. Frequency of the thermolabile variant C677T in the MTHFR gene and lack of association with neural tube defects in the state of Yucatan, México. Clinical Genetics. 62:394-398.

17.- Yocupicio-Monroy, R.M.E., Medina, F., Reyes-del Valle, J., and del Angel, R.M. 2003. Cellular proteins from human monocytes bind to dengue 4 virus minus-strand 3’ untranslated region RNA. J. Virol. 77:3067-3076.

18.- Aguilar-Maldonado, B., Gómez-Viquez, L., García, L., del Angel, R.M., Arias Montaño, J.A. and Guerrero-Hernández, A. 2003. Histamine potentiates IP3-mediated Ca2+ release via thapsigargin-sensitive Ca2+ pumps. Cellular Signalling 15:689-697.

19.- Reyes del Valle, J. and del Angel, R.M. 2004. Isolation of putative dengue virus receptor molecules by affinity chromatography using a recombinant E protein ligand. J. Virol. Meth.116:95-102.

20.- García-Montalvo, B.M., Medina, F., and del Angel, R.M. 2004. La Protein binds to NS5 and NS3 and to the 5’ and 3’ ends of Dengue 4 Virus RNA. Virus Res. 102:142-150.

21.- Reyes del Valle, J., Chavez-Salinas, S, Medina F and del Angel, R.M. 2005. Heat shock protein 90 and heat shock protein 70 are components of Dengue virus receptor complex in human cells. J. Virol. 79:4557-4567.

22.- del Angel, R.M. Chávez-Salinas, S., Ceballos-Olvera, I., Medina-Ramírez, F. y Reyes-del Valle, J. 2006. Proteínas celulares involucradas en la unión y entrada del virus del dengue. Revista Latinoamericana de Microbiología 48: 197-198.

23.- Yocupicio-Monroy, M., Padmanabhan, R., Medina, F, and del Angel, R.M. 2007. Mosquito La protein binds to the 3’ Untranslated Region of the Positive and Negative Polarity Dengue virus RNAs and Relocates to the Cytoplasm of Infected Cells. Virology. 357: 29-40.

24.- González Durán, E., del Angel, R.M. and Salas Benito J.S. 2007. In Vitro interaction of poliovirus with cytoplasmic dynein. Intervirology. 50: 214-218.

25.-Salas-Benito, J., Reyes-Del Valle, J., Salas-Benito, M., Ceballos-Olvero, I., Mosso, C. And Del Angel, R.M. 2007. The 45 kDa glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6/36, is a heat shock related protein. Am. J. Trop. Med. Hyg. 77: 283-290.

26.- Ludert, J.E., Mosso, C., Ceballos-Olvera I, and del Angel R.M. 2008. Use of a comercial enzyme immunoassay to monitor dengue virus replication in cultured cells. Virology J. 5:51

27.- Mosso, C., Galván-Mendoza, I.J., Ludert, J.E. and del Angel, R.M. 2008. Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 378:193-199.

28.- Chavez-Salinas, S., Ceballos-Olvera, I., Reyes-del Valle, J., Medina, F., del Angel, R.M. 2008. Heat shock effect upon dengue virus replication into U937 cells. Virus Res. 138: 111-118.

29.- Agis-Juarez RA, Galvan I, Medina FJ, Daikoku T, Padmanabhan R, Ludert JE, Del Angel RM. 2009. The Polypyrimidine-Tract Binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells. J Gen Virol. 90: 2893-2901.

30.- Ceballos-Olvera I, Chávez-Salinas S, Medina F, Ludert JE, Del Angel RM. 2010. JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology 396: 30-36.

31.- Puerta-Guardo H, Mosso C, Medina F, Liprandi F, Ludert JE, Del Angel RM. 2010. The antibody dependent enhancement (ADE) of dengue virus infection in U937 cells requires cholesterol rich membrane microdomains. J Gen Virol 91:394-403.

32.- Alcaraz-Estrada SL, Manzano MI, Del Angel RM, Levis R, Padmanabhan R. 2010. Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5. J Gen Virol. 91:2713-2718.

33.- Alcaraz-Estrada, S.L., Yocupicio-Monroy M. and del Angel R. M. 2010. Insights into dengue virus genome replication. Future Virology 5: 575-592.

34.- de la Cruz Hernandez, S.I., González Mateos, S., Flores Aguilar, H., López Martínez, I.,Alpuche Aranda, C., Ludert, J.E., del Angel, R.M. 2012. Evaluation of a novel comercial rapid test for dengue diagnosis base don specific IgA detection. Diagn Microbiol. Infect Dis.  72:150-155.

35.- Puerta-Guardo, H. De la Cruz Hernández, S.I., Rosales, V.H., Ludert, J.E. and del Angel, R.M. 2012. The 1 alfa, 25-Dyhidroxy-Vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res 94:57-61

36.- Juárez-Martínez, A.B., Salas-Benito, M., García-Espitia. M. De Nova-Ocampo, M. del Ángel, R.M. and Salas-Benito, J.S. 2013. Detection and sequencing of defective viral genomes in C6/36 cells persistently infected with dengue virus 2. Arch Virol. 158:583-599.

37.- De la Cruz-Hernandez, S.I., Flores-Aguilar, H., Gonzalez-Mateos, S., Lopez-Martinez, I., Alpuche-Aranda, C., Ludert, J.E., del Angel, R.M. 2013. Determination of viral load and concentration of circulating NS1 protein in an open mexican population infected with dengue virus. Am. J. Trop. Med Hyg. 88:446-454.

38.- Vega-Almeida TO, Salas-Benito M, De Nova-Ocampo MA, Del Angel RM, Salas-Benito JS.- 2013. Surface proteins of C6/36 cells involved in dengue virus 4 binding and entry.- Arch Virol. 158:1189-1207

39.- Soto-Acosta R, Mosso C, Cervantes-Salazar M, Puerta-Guardo H, Medina F, Favari L, Ludert JE, del Angel RM. 2013. The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity. Virology.442:132-147.

40. Puerta-Guardo H, Sandino AR, González-Mariscal L, Rosales VH, Ayala-Dávila J, Chávez- Mungía B, Martínez-Fong D, Medina F, Ludert JE, Del Angel RM. 2013. The cytokine response of U937-derived macrophages infected through antibody dependent enhancent of dengue virus disrupts cell apical junctional complexes and increase vascular permeability. J Virol. 87:7486-7501

41.- De La Cruz Hernández SI, Ortiz-Navarrete V, Ludert JE, Del Angel RM. 2013. Dengue specific IgM seropositivity correlates with severe clinical outcome J Clin Virol. 58:751.

42.- De La Cruz Hernández SI, Flores-Aguilar H, González-Mateos S, López-Martínez I, Ortiz-Navarrete V, Ludert JE, Del Angel RM.- 2013. Viral load in patients infected with dengue is modulated by the presence of anti-dengue IgM antibodies.- J Clin Virol. 58:258-61.

43.- Del Angel RM, Reyes-del Valle J.- 2013. Dengue vaccines: strongly sought but not a reality just yet.- PLoS Pathog.;9(10):e1003551. doi: 10.1371/journal.ppat.1003551. Oct 3. PMID:24098108.

44.- · Reyes-del Valle, J., Salas-Benito J., Soto-Acosta, R., and del Angel R.M. 2014. Dengue virus celular receptors and tropism. Current Trop. Med. Reports. 1:36-43.

45.- Alcaraz-Estrada SL, Del Angel R, Padmanabhan R. 2014. Construction of self-replicating subgenomic dengue virus 4 (DENV4) replicon. Methods Mol Biol. 2014;1138:131-50.

46.- De La Cruz Hernández SI, Puerta-Guardo H, Flores-Aguilar H, González-Mateos S, López- Martinez I, Ortiz-Navarrete V, Ludert JE, Del Angel RM. 2014. A strong interferon response correlates with a milder dengue clinical condition. J Clin Virol. 60:196-199.

47.- Salazar MI, Del Angel RM, Lanz-Mendoza H, Ludert JE, Pando-Robles V. 2014. The role of cell proteins in dengue virus infection. J Proteomics. 111:6-15.

48.- Soto-Acosta R, Bautista-Carbajal P, Syed GH, Siddiqui A, Del Angel RM. 2014. Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus. Antiviral Res. 109:132-140.

49.- Cabrera-Romo, S., Recio-Totoro, B., Alcala , Ana C., Lanz, H., del Angel, R.M. Sanchez-Cordero, V., Rodriguez-Moreno, A. and Ludert, J.A. 2014. Experimental Inoculation of Artibeus jamaicensis Bats with Dengue Virus Serotypes 1 or 4 Showed No Evidence of Sustained Replication. Am J. Trop.Med & Hyg. 91:1227-1234.

50.- Betancourt-Cravioto M, Kuri-Morales P, González-Roldán JF, Tapia-Conyer R;

Mexican Dengue Expert Group. 2014. Introducing a dengue vaccine to Mexico: development of a system for evidence-based public policy recommendations. PLoS Negl Trop Dis. 31:e3009. doi: 10.1371/journal.pntd.0003009.

51.- Escalera-Cueto M, Medina-Martínez I, del Angel RM, Berumen-Campos J, Gutiérrez-Escolano AL, Yocupicio-Monroy M. 2015. Let 7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells. Virus Res. 196:105-112.

52.- González-Calixto C, Cázares-Raga FE, Cortés-Martínez L, Del Angel RM, Medina-Ramírez F, Mosso C, Ocádiz-Ruiz R, Valenzuela JG, Rodríguez MH, Hernández-Hernández FC. 2015. AealRACK1 expression and localization in response to stress in C6/36 HT mosquito cells. J Proteomics 119C:45-60.

53.- Angel-Ambrocio AH, Soto-Acosta R, Tammineni ER, Carrillo ED, Bautista-Carbajal P, Hernández A, Sánchez JA, Del Angel RM. 2015. An embryonic heart cell line is suceptible to dengue virus infection. Virus Res 198: 53-58.

54.- De La Cruz Hernández, SI, Reyes-del Valle, J, Villegas-del Angel, E., Ludert JE and del Angel RM. 2015. Dengue Laboratory Diagnosis: still some room for improvement . Future Virol. 10: 845-857

55.- Cervantes-Salazar, M, Angel-Ambrocio, AH, Soto-Acosta, R, Bautista-Carbajal, P, Hurtado-Monzón, AM, Alcaraz-Estrada, SL, Ludert, JE, Del Angel, RM. 2015. Dengue virus NS1 protein interacts with the ribosomal protein RPL18: This interaction is required for viral translation and replication in Huh-7 cells. Virology 484: 113–126.

56.- Alcalá AC, Medina F, González-Robles A, Salazar-Villatoro L, Fragoso-Soriano RJ, Vásquez C, Cervantes-Salazar M, Del Angel RM, Ludert JE. 2016. The dengue virus non-structural protein 1 (NS1) is secreted efficiently from infected mosquito cells. Virology. 488:278-287.

57.- de la Cruz Hernández SI, Puerta-Guardo HN, Flores Aguilar H, González Mateos S, López Martinez I, Ortiz-Navarrete V, Ludert JE, Del Angel RM.  2016. Primary dengue virus infections induce differential cytokine production in Mexican patients. Mem Inst Oswaldo Cruz 111: 161-167.

58.- Cabrera-Romo S, Max Ramirez C, Recio-Tótoro B, Tolentino-Chi J, Lanz H, Del Ángel RM, Sánchez-Cordero V, Rodríguez-Moreno Á, Ludert JE. 2016. No Evidence of Dengue Virus Infections in Several Species of Bats Captured in Central and Southern Mexico. Zoonoses Public Health. 63:579-583.

59.- Bautista-Carbajal P, Soto-Acosta R, Angel-Ambrocio AH, Cervantes-Salazar M, Loranca-Vega CI, Herrera-Martínez M, Del Angel RM. 2017. The calmodulin antagonist W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) inhibits DENV infection in Huh-7 cells. Virology 501:188-198.

60.- Avila-Bonilla RG, Yocupicio-Monroy M, Marchat LA, De Nova-Ocampo MA, Del Ángel RM, Salas-Benito JS. 2017. Analysis of the miRNA profile in C6/36 cells persistently infected with dengue virus type 2. Virus Res. 232:139-151

61.- Soto-Acosta, R., Bautista-Carbajal, P, Cervantes-Salazar, M, Angel Ambrocio, AH and del Angel R.M 2017. DENV Up-Regulates the HMG-CoA Reductase Activity through the Impairment of AMPK Phosphorylation: A Potential Antiviral Target. Plos Pathogen. 10.1371/journal.ppat.1006257.

62.- Alcalá AC, Hernández-Bravo R, Medina F, Coll DS, Zambrano JL, Del Angel RM, Ludert JE. 2017. The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway. J Gen Virol. 98:2088-2099.

63.- Trujillo-Ocampo A, Cázares-Raga FE, Del Angel RM, Medina-Ramírez F, Santos-Argumedo L, Rodríguez MH, Hernández-Hernández FC. 2017. Participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in Aedes mosquito cell lines. Parasit Vectors 10:362.

64.- Dionicio CL, Peña F, Constantino-Jonapa LA, Vazquez C, Yocupicio-Monroy M, Rosales R, Zambrano JL, Ruiz MC, Del Angel RM, Ludert JE. 2018. Dengue virus induced changes in Ca2+ homeostasis in human hepatic cells that favor the viral replicative cycle. Virus Res. 245:17-28.

65.- Reyes-Ruiz JM, Osuna-Ramos JF, Cervantes-Salazar M, Lagunes Guillen AE, Chávez-Munguía B, Salas-Benito JS, Del Ángel RM. 2018. Strand-like structures and the nonstructural proteins 5, 3 and 1 are present in the nucleus of mosquito cells infected with dengue virus. Virology. 515:74-80.

66.- Elizondo-Quiroga D, Medina-Sánchez A, Sánchez-González JM, Eckert KA, Villalobos-Sánchez E, Navarro-Zúñiga AR, Sánchez-Tejeda G, Correa-Morales F, González-Acosta C, Arias CF, López S, Del Ángel RM, Pando-Robles V, Elizondo-Quiroga AE. 2018. Zika Virus in Salivary Glands of Five Different Species of Wild-Caught Mosquitoes from Mexico. Scientific Rep. 8:809. doi: 10.1038/s41598-017-18682-3.

67. - Osuna-Ramos JF, Rendón-Aguilar H, Reyes-Ruiz JM, Del Ángel RM, Romero-Utrilla A, Ríos-Burgueño ER, Velarde-Rodriguez I, Velarde-Félix JS. 2018. The correlation of TNF alpha levels with the lipid profile of dengue patients.

J. Med Virol. 90:1160-1163.

68.- Apodaca-Medina AI, Torres-Avendaño JI, Rendón-Maldonado JG, Torres-Montoya EH, Flores-López BA, Del Angel RM, Velarde-Félix JS, Salomón-Soto VM, Castillo-Ureta H. 2018. First Evidence of Vertical Infection of Dengue Virus 2 in Aedes aegypti Mosquitoes from Sinaloa, Mexico. Vector Borne Zoonotic Dis. 18:231-233.

69.- Taboada B, Isa P, Gutiérrez-Escolano AL, Del Ángel RM, Ludert JE, Vázquez N, Tapia-Palacios MA, Chávez P, Garrido E, Espinosa AC, Eguiarte LE, López S, Souza V, Arias CF. 2018. The viral structure of the Cuatro Ciénegas Basin, a unique oasis in Northern Mexico, reveals a highly diverse population at a small geographic scale. Appl Environ Microbiol. AEM.00465-18. doi: 10.1128/AEM.00465-18.

70.- Ramirez L, Betanzos A, Raya A, González-Mariscal L, Del Angel RM. 2018. Dengue virus enters and exits epithelial cells through both apical and basolateral surfaces and perturbs the apical junctional complex. Virus Res. 258:39-49. doi: 10.1016/j.virusres.2018.09.016.

71.- Osuna-Ramos JF, Reyes-Ruiz JM, Bautista-Carbajal P, Cervantes-Salazar M, Farfan-Morales CN, De Jesús-González LA, Hurtado-Monzón AM, Del Ángel RM. 2018. Ezetimibe inhibits dengue virus infection in Huh-7 cells by blocking the cholesterol transporter Niemann-Pick C1-like 1 receptor. Antiviral Res. 160:151-164.

72.- Osuna-Ramos JF, Reyes-Ruiz JM, Del Ángel RM. 2018. The Role of Host Cholesterol During Flavivirus Infection. Front Cell Infect Microbiol. 8:388. doi: 10.3389/fcimb.2018.00388.

73.- Tammineni ER, Carrillo ED, Soto-Acosta R, Angel-Ambrocio AH, García MC, Bautista-Carbajal P, Del Angel RM, Sánchez JA. 2018. The β4 subunit of Cav1.2 channels is required for an optimal interferon response in cardiac muscle cells. Sci Signal. 11(560). pii: eaaj1676. doi: 10.1126/scisignal.aaj1676.

74.- Reyes-Ruiz JM, Osuna-Ramos JF, Bautista-Carbajal P, Jaworski E, Soto-Acosta R, Cervantes-Salazar M, Angel-Ambrocio AH, Castillo-Munguía JP, Chávez-Munguía B, De Nova-Ocampo M, Routh A, Del Ángel RM, Salas-Benito JS. 2019. Mosquito cells persistently infected with dengue virus produce viral particles with host-dependent replication. Virology. 531:1-18. doi: 10.1016/j.virol.2019.02.018.

75.- Reyes-Ruiz JM, Osuna-Ramos JF, De Jesús-González LA, Hurtado-Monzón AM, Farfan-Morales CN, Cervantes-Salazar M, Bolaños J, Cigarroa-Mayorga OE, Martín-Martínez ES, Medina F, Fragoso-Soriano RJ, Chávez-Munguía B, Salas-Benito JS, Del Angel RM. 2019. Isolation and characterization of exosomes released from mosquito cells infected with dengue virus. Virus Res. 266:1-14. doi: 10.1016/j.virusres.2019.03.015.

 

PARTICIPACIÓN EN CONGRESOS INTERNACIONALES   146

ESTUDIANTES GRADUADOS

MAESTRÍA  38

DOCTORADO  24

 

DISTINCIONES:

1.- Mención Honorífica. Universidad La Salle. 1986

2.- Premio de investigación médica Syntex. 2003.

3.- Miembro de la Academia Mexicana de Ciencias desde 2003.

4.- State of the Art Lecturer. American Society for Virology Meeting. Montreal, Canada. 2004.

5.- Latin American Professor Award. American Society for Virology Meeting. Penn State University. 2005.

6.- Flavivirus session Convenor. American Society for Virology Meeting. Penn State University. 2005.

7.- Flavivirus III session Convenor American Society for Virology. Madison University. 2006.

8.- Miembro de la UC MEXUS-CONACYT fellowships and grants review committee for Health and Medical Sciences.  University of California. 2008.

9.- Miembro del Organizing Committee of the First Pan American Dengue Research Network Meeting in Recife, Brazil, del 22 al 25 de julio de 2008.

10.- Miembro de la Comisión de evaluación de Proyectos de Investigación Cientifica básica de CONACYT. 2008-2012.

11.- Miembro of the National System of Researchers level 3. 2012.

12.- Miembro del Organizing Committee of the First Pan American Dengue Research Network Meeting in Cancun, Mexico, 2010

13.- Miembro de la Comisión evaluadora del Sstema Nacional de Investigadores. 2012-2015.

14.- Miembro del Comité Editorial de “Virology”. 2016-2019.

15.- Miembro del Comité Editorial de “Current opinion in Virology”. 2013.

16.- Responsable de la Red Mexicana de Virología. 2015-2016.

17.- Jefe del Departamento de Infectómica y Patogénesis Molecular. 2015-ahora.

18.- Miembro de la Red de Expertos en Dengue de México. 2012-ahora.

19.- Plenary lecturer. 5th PanDengue Network Meeting. Panama. 2016.

20.- Premio Langebio a la mejor tesis de doctorado del Dr. Henry Puerta-Guardo. 2015

21.- Premio Arturo Rosenblueth a la mejor tesis de doctorado del Cinvestav al Dr. Ruben Soto-Acosta. 2017.

22.- Premio Miguel Alemán 2017.

23.- Premio Miguel Alemán 2018.

24.- Presidenta de la Comisión de Reconsideraciones del Sistema Nacional de Investigadores (Area 2) 2018.

23.- Plenary lecturer. 6th PanDengue Network Meeting. Galveston. 2018.